作者Eklio?luBS等单位土耳其艾尔巴坎医科大学儿科原题PrediabetesandCardiovascularParametersinObeseChildrenandAdolescents.报道据《JClinResPediatrEndocrinol》年3月报道中文译文
土耳其艾尔巴坎医科大学儿科的Eklio?luBS等进行了一项研究，评估了肥胖儿童和青少年的心血管风险和心脏功能。
研究共纳入例6～18岁的肥胖儿童和青少年。测量了人体学数据、血压、口服葡萄糖耐量试验、血脂和HbA1c。根据美国糖尿病学会的标准确定是否为糖尿病前期。同时检测左室肥厚指数（LVMi）、颈动脉内-中膜厚度（c-IMT）和组织多普勒。
结果显示，糖尿病前期组的LVMi显著升高（p=0.03）。糖尿病前期组和非糖尿病前期组的右室组织多普勒扫描未见统计学差异。糖尿病前期组的左室多普勒扫描显著升高：LVEEM（左室E/e，p=0.04）；LVEM（左室心肌速率cm/s，p=0.）。LVMi与甘油三酯、舒张压、腰围、体重标准差值呈正相关，与高密度脂蛋白胆固醇呈负相关（p=0.，r=0.15；p=0.，r=0.15；p=0.，r=0.17；p=0.，r=0.19；p=0.，r=-0.15）。LVEM与血糖相关（p=0.，r=0.15），LVEEM与收缩压相关（p=0.，r=0.15）。线性回归分析显示临床心血管风险因子和空腹血糖水平是LVEM的最佳预测因子。
研究表明，糖尿病前期肥胖儿童和青少年患者的心脏功能出现恶化。推荐尽早发现糖尿病前期肥胖儿童和青少年的心血管风险因素。
英文原文OBJECTIVE
Inthisstudy,ouraimwastodeterminecardiovascularriskandcardiacfunctioninprediabeticobesechildrenandadolescents.
METHODS
Thestudywasconductedonobesechildrenandadolescents6-18yearsofage.Anthropometricmeasurements,bloodpressuremeasurements,oralglucosetolerancetest,lipidprofile,andHbA1clevelsofpatientswereassessed.PrediabeteswasdefinedaccordingtoAmericanDiabetesAssociationcriteria.Leftventricularmassindex(LVMi),carotidintima-mediathickness(c-IMT),andtissueDopplermeasurementsrecordswereused.
RESULTS
LVMiwasfoundtobesignificantlyhigherintheprediabetesgroup(p=0.03).TherewerenostatisticallysignificantdifferencesinrightventriculartissueDopplermeasurementsbetweentheprediabeticandnon-prediabeticgroups.LeftventriculartissueDopplermeasurementsweresignificantlyhigherintheprediabetesgroup:LVEEM(leftventricularE/eratio)(p=0.04);LVEM(leftventricularmyocardialvelocitycm/s)(p=0.).LVMiwasfoundtopositivelycorrelatewithtriglyceridelevel,diastolicbloodpressure,waistcircumference,bodyweightstandarddeviationscoreandtonegativelycorrelatewithhigh-densitylipoproteincholesterol(p=0.,r=0.15;p=0.,r=0.15;p=0.,r=0.17;p=0.,r=0.19;p=0.,r=-0.15,respectively).LVEMwascorrelatedwithglucose(p=0.,r=0.15)andLVEEMwascorrelatedwithsystolicbloodpressure(p=0.,r=0.15).Inlinearregressionanalysisforclinicalcardiovascularriskfactors,fastingglucoselevelwasthebestpredictorofLVEM.
CONCLUSION
Inthisstudy,deteriorationofcardiacfunctioninprediabeticobesechildrenandadolescentswasshown.Were
